PEANUT ALLERGY GOES WITH NASAL MIST VACCINE

Allergies are among the most common chronic conditions worldwide. Allergy symptoms range from making you miserable to putting you at risk for life-threatening reactions. Early identification of childhood allergies will improve your child’s quality of life, reduce the number of missed school days and help you avoid having to use sick time or vacation days to care for your child.

An allergic reaction typically triggers symptoms in the nose, lungs, throat, sinuses, ears, lining of the stomach or on the skin. For some people, allergies can also trigger symptoms of asthma. In the most serious cases, a life-threatening reaction called anaphylaxis can occur. Anaphylaxis is a serious, life-threatening allergic reaction. The most common anaphylactic reactions are to food, insect stings, medications and latex.

Recent study reports say that a vaccine delivered as an ultrafine nasal spray was found to limit or prevent peanut allergy symptoms in mice. This study is the first step in potentially developing a vaccine to treat food allergies in humans. Researchers with the Mary H. Weiser Food Allergy Center at the University of Michigan developed the vaccine as a new form of immunotherapy to treat allergies to peanut. During an allergic reaction, the body's immune system overreacts to an allergen, that is, an otherwise harmless protein. Allergen immunotherapy attempts to retrain the immune system to tolerate the allergen. Other peanut allergy immunotherapies being tested in human clinical trials have been shown to improve peanut tolerance in many, but not all, peanut allergy patients. This tolerance can be lost if maintenance doses of peanut are discontinued; additionally, adverse reactions can occur during immunotherapy.

The vaccine research team is working to develop a safe, durable and more widely effective new form of immunotherapy. The experimental immunotherapy vaccine consists of peanut protein and nano-emulsion, tiny droplets of highly purified soybean oil, detergents and water mixed at high speed. The average diameter of the droplets is 350-400 nanometers, roughly 200 times smaller than the average diameter a human hair. Nani-emulsion acts as an adjuvant to increase the immune response in the body. Henceforth this immune fighting response suppresses the Allergic reactions.

The mice were sensitized to Peanut to carry out the Allergic effects, they were given the dose of Nasal Vaccine for a period of two months and the comparison was noted with the mice with the influence of Nasal Vaccine and the mice with placebo. Results showed that mice which underwent the influence of
Nasal Vaccine were protected against allergic symptoms like severe symptoms of puffy eyes, wheezing and shock.

Many more studies going on to improve the longer activity of the Vaccine effect. Future studies may reveal more mechanisms responsible for the protection against the allergic reactions.

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